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August 25, 1945

THE GIANT CELLS IN HODGKIN'S DISEASE-ANCIENT ERROR IN MODERN MEDICINE

JAMA. 1945;128(17):1248-1249. doi:10.1001/jama.1945.02860340054021

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Abstract

To the Editor:—  It is difficult to determine just who is responsible for the preservation in modern medicine of the ancient error that the giant cells in the tissues of Hodgkin's disease were first described by the Austrian investigator Sternberg or by Dorothy Reed, an American. As a matter of truth they were first described by an Englishman, Greenfield, in 1878, twenty years before Sternberg called attention to them in 1898 and twenty-four years before the appearance of Reed's paper in 1902 and Andrew's paper at about the same time. Nevertheless these cells are frequently referred to as Sternberg's cells or as Dorothy Reed cells or as Sternberg-Reed cells and practically never as Greenfield's cells. In his presentation to the Pathological Society of London on April 2, 1878 on "Specimens Illustrative of the Pathology of Lymphadenoma and Leukocythemia," Greenfield followed the English custom of using the designation lymphadenoma synonymously with

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