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In this monograph the author presents his experience in the diagnosis and management of diabetic patients with gangrene of the lower extremities. A detailed study of 39 cases is included. Oscillometric studies, histamine tests and Samuel's maneuver of induced plantar ischemia were carried out and found to be reliable. In order to rule out vascular spasm, Landis and Gibson's test and the intravenous injection of sodium nitrite were used, following the technic of Beck and Takats. The patients' conditions did not lend themselves to arteriography, although the author is aware of the value of this procedure in verifying the degree of diminution or occlusion of the arterial lumen.
Contribuição ao estudo das gangrenas dos membros inferiores nos diabéticos. JAMA. 1945;128(17):1258. doi:10.1001/jama.1945.02860340064029
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