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September 1, 1945


Author Affiliations
Fellow in Medicine, Mayo Foundation ROCHESTER, MINN.
From the Division of Medicine, Mayo Clinic (Dr. Hines).
JAMA. 1945;129(1):1-4. doi:10.1001/jama.1945.02860350003001

It has been assumed that Raynaud's disease occurs very rarely among men as compared with its occurrence among women. From both a diagnostic and a prognostic standpoint it is important that the physician be able to recognize Raynaud's disease both among men and among women and to distinguish it from other peripheral vascular diseases, especially from those in which there occurs a secondary form of Raynaud's phenomenon. The differential diagnosis of Raynaud's disease is more difficult among men than among women because of the relative infrequency of Raynaud's disease among men in comparison with the organic peripheral vascular diseases which may produce similar vasospastic phenomena in the extremities.

In reviewing 200 cases of thromboangiitis obliterans, Allen and Brown1 found that Raynaud's phenomenon was the first symptom in 12 per cent and that it occurred at some time during the course of the disease in 30 per cent of all