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September 1, 1945

THE EFFECTS OF CONCENTRATED HYPERIMMUNE RABBIT SERUM IN LOUSE BORNE TYPHUS

JAMA. 1945;129(1):19-24. doi:10.1001/jama.1945.02860350021005
Abstract

The treatment of classic louse borne typhus with immune serum of various types has been described in many reports. Most of the attempts indicated that human convalescent serum had no noticeable effect on the course of typhus. The serums obtained from animals after they had recovered from experimental typhus have also been given a clinical trial, but the reports of the therapeutic value of such serums have been somewhat conflicting. The early literature has been reviewed by Otto and Munter.1

More recently the development of satisfactory technics for the cultivation of rickettsias in large quantities has facilitated the hyperimmunization of animals. Zinsser, Castaneda and Hager2 prepared a serum by inoculation of horses with rich suspensions of murine rickettsias obtained from x-rayed rats. Durand and Balozet, by inoculations with rickettsias from infected lungs of rodents, obtained a hyperimmune horse serum against epidemic louse borne typhus,3 which was reported

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