With the introduction of pure vitamins, particularly members of the B complex, interest in the possibility of interrelation of vitamin activity has been stimulated. In the clinical literature are suggestions of the possible interrelation or antagonism of some of the B vitamins. Pellagrins often show symptoms of thiamine or riboflavin deficiency after receiving nicotinic acid; the added niacin may either increase the thiamine or riboflavin requirement of the pellagrin or actually antagonize the effect of the small amounts of the other B vitamins present. In addition, the possibility of producing an improper balance of vitamins should also be considered. This may now be easy to achieve, since there are many pure preparations of vitamins available allowing for the administration of unphysiologic doses of a given vitamin.
Early attempts to produce a deficiency of one of the B vitamins by overdosing with other members of the complex have not met with
VITAMIN IMBALANCE. JAMA. 1945;129(1):74. doi:10.1001/jama.1945.02860350076016
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