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November 25, 2019

Implementation Strategies for Cardiovascular Polypills

Author Affiliations
  • 1Feinberg School of Medicine, Department of Preventive Medicine, Northwestern University, Chicago, Illinois
  • 2The George Institute for Global Health, University of New South Wales, Sydney, Australia
  • 3The George Institute for Global Health, University of New South Wales, Hyderabad, India
JAMA. 2019;322(23):2279-2280. doi:10.1001/jama.2019.18102

Robust data from population- and genetic-based studies support the causal relationship of serum cholesterol and blood pressure levels with atherosclerotic cardiovascular disease (ASCVD) events.1 High-quality randomized trials have demonstrated the independent benefits of cholesterol and blood pressure lowering in reducing incident and recurrent ASCVD events with commonly used and low-cost medicines, including statins and blood pressure–lowering drugs.2,3 Despite evidence and endorsement of simultaneously targeting multiple risk factors for the prevention of ASCVD events, the specific approach of using fixed-dose combinations of cholesterol- and blood pressure–lowering drugs (and aspirin in the context of secondary prevention), also known as polypills, remains limited.

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