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September 1, 1945

NICOTINIC ACID IN VINCENT'S ANGINA

Author Affiliations

Winston-Salem, N. C.

JAMA. 1945;129(1):91. doi:10.1001/jama.1945.02860350093025

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Abstract

To the Editor:—  In The Journal, July 7, are two interesting articles on the use of penicillin in Vincent's angina. From the experience of Captain Schwartz and of Major Shallenberger, Lieutenant Colonel Denny and Major Pyle there is no reason to doubt that penicillin is quite effective in acute cases of Vincent's angina. I am writing, not to question the effectiveness of penicillin, but to suggest that nicotinic acid (or niacin) or nicotinamide has been found by myself and a number of others to be just as effective as penicillin in such cases. Since it is much simpler to take a 50 mg. tablet three times a day than to have an intramuscular injection every three hours for five doses, or even to have penicillin applied locally every four hours, it seems logical to use nicotinic acid first.So far as I know, J. B. King first called attention to

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