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September 8, 1945


JAMA. 1945;129(2):104-108. doi:10.1001/jama.1945.02860360006002

Before regional ileitis was established as a disease entity by Crohn and his co-workers1 in 1932, this condition was thought to be a form of tuberculous enteritis. In many instances the existence of a small intestinal lesion was not even recognized, owing to a well known lag in the development of both clinical and roentgenologic diagnosis of disease of the small intestine.

DIAGNOSIS  Our first diagnoses of regional ileitis were made in flagrant cases of this condition with extensive and chronic lesions. As we have learned more concerning the clinical course and the corresponding pathologic changes that occur in the wall of the small bowel, the diagnosis has been made in the earlier stages and in instances of less extensive disease.In any attempt to set up minimal criteria for the diagnosis of regional ileitis, the acute forms must be considered separately from the chronic stage.The onset of