The origin, preparation and action of penicillin in medicine have been so well described in the literature that I shall not discuss these subjects. Suffice it to say that penicillin is an antibiotic of the greatest importance against certain organisms whether used locally, intramuscularly, intravenously, subcutaneously, intrathecally or by a combination of these methods.
Dosage and methods of administration have not been thoroughly standardized. Cooke and Goldring1 showed that after intramuscular injections of penicillin the concentration in the circulating blood reached its highest level within thirty minutes. It was still moderately high at the end of one hour and fell rapidly during the second hour but often persisted at lower titer for three to four hours. They found similar results after subcutaneous injection of penicillin.
Swanson and Baker2 used penicillin intramuscularly in 15 cases of acute otitis media and locally in the mastoid cavity following mastoidectomy with controlled
ALLMAN CH. PENICILLIN IN OTOLOGY: ITS USE IN 511 CASES OF OTITIS MEDIA AND 74 CASES OF MASTOIDITIS. JAMA. 1945;129(2):109–112. doi:10.1001/jama.1945.02860360011003
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