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September 8, 1945

RAPID DEVELOPMENT OF CARRIER STATE AND DETECTION OF POLIOMYELITIS VIRUS: IN STOOL NINETEEN DAYS BEFORE ONSET OF PARALYTIC DISEASE

JAMA. 1945;129(2):121-123. doi:10.1001/jama.1945.02860360023006
Abstract

Well established is the fact that the virus of poliomyelitis may be demonstrated in the stools of a high percentage of cases of the disease and that in some it may be present for varying lengths of time up to several weeks1 and even months2 after the onset of clinical disease. Virus has been recovered from the oropharynx in approximately 50 per cent of the cases when swabs or washings were obtained within a few days of the onset of paralysis,3 but its detection in this site is uncommon after the fifth day of disease.4

Presumptive evidence of the harboring of the virus for a considerable period prior to the onset of disease has been advanced by Francis and his associates,5 who described 5 cases of poliomyelitis with three deaths following tonsillectomy in children probably carrying the virus.

Taylor and Amoss6 demonstrated virus in

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