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September 8, 1945

SEDATION AS AN UNEXPECTED SYSTEMIC EFFECT OF PRIVINE

JAMA. 1945;129(2):129. doi:10.1001/jama.1945.92860360001008
Abstract

Three cases are reported in which privine hydrochloride produced sedation. This effect might not have been anticipated from the general character of the drug, which gives a complicated type of systemic stimulation in animals. Trial observations by Drs. F. M. Martin and R. P. Walton in the Department of Pharmacology disclosed that intravenous doses in 4 rats and 3 dogs produced hyperpnea, gross muscle spasms, occasional reflex hyperexcitability and convulsions. The effects of fatal doses suggestively resembled acute epinephrine deaths.

The clinical observations have a parallel in the systemic actions of ephedrine, which is ordinarily a stimulant or analeptic drug in adults. In a report by Bonzanigo1 ephedrine was found to produce sedative effects frequently in children between the ages of 3 months and 14 years. Ephedrine was given to these patients in doses large enough to produce the characteristic hypertension.

Case 1.  —A girl aged 7 years, with vasomotor rhinitis

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