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September 8, 1945

CURARE IN THE ACUTE STAGE OF POLIOMYELITIS: PRELIMINARY REPORT

JAMA. 1945;129(2):129-130. doi:10.1001/jama.1945.92860360001008a
Abstract

A preparation of curare1 has been used in the Orthopedic Service of the Monmouth Memorial Hospital in the past 4 consecutive cases of acute anterior poliomyelitis. In view of the present prevalence of this disease and the striking improvement of the symptoms obtained, the publication of the present preliminary report seems warranted.

REPORT OF CASES 

Case 1.  —D. G., a girl aged 2½ years, was admitted with acute anterior poliomyelitis. Nuchal rigidity was pronounced, and there were rigidity of the entire back, hamstring spasm on both sides and gastrocnemius spasm on the right. The patient was treated in the routine way for ten days and was then given 0.9 mg. of curare per kilogram. Within two hours after the initial administration of the drug the child was sitting up in bed and playing for the first time. There was definite diminution of the nuchal rigidity and in the rigidity

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