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Comment & Response
December 10, 2019

Treatment of Hyperglycemia in Patients With Acute Stroke—Reply

Author Affiliations
  • 1Department of Neurology, Medical College of Georgia, Augusta
  • 2Department of Neurology, University of Virginia, Charlottesville
  • 3Department of Public Health Sciences, Medical University of South Carolina, Charleston
JAMA. 2019;322(22):2248-2249. doi:10.1001/jama.2019.16342

In Reply Dr Long and colleagues point out that the SHINE trial1 may have shown additional useful results if patients were stratified based on prestroke glycemic control. Although the sample of patients without diabetes was small, eFigure 1 in Supplement 3 in the article showed that there was no significant difference in the primary outcome by treatment group in the subgroups of patients with or without diabetes. We are in the process of conducting secondary analyses to assess hemoglobin A1c levels and outcome.