In his classic monograph "Ueber den Zusammenhang von Herz und Nierenkrankheiten," Traube postulated in 1856 the compensatory theory of the development of elevated arterial pressure in diseases of the kidneys. He considered the elevation of the arterial pressure an effort on the part of the organism to overcome the mechanical resistance against blood flow and an effort to maintain the excretory function of the kidneys. With the introduction of accurate measurement of the blood pressure, hypertension was found to be one of the most frequent complications of renal disease. The conclusion was drawn that renal influences in some way contributed to the hypertension.
In an attempt to determine the nature of renal influence in hypertension, Page and Heuer1 performed bilateral renal denervation on a patient suffering from essential hypertension uncomplicated by recognizable renal involvement and with but slight evidence of anatomic changes in the circulatory system. The level of
SURGICAL TREATMENT OF MALIGNANT HYPERTENSION. JAMA. 1937;108(8):642–643. doi:10.1001/jama.1937.02780080036015
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