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February 20, 1937


JAMA. 1937;108(8):643. doi:10.1001/jama.1937.02780080037016

Rapid introduction into the blood stream of a number of substances was shown by Hyman and Hirshfeld1 in animal experiments to result in a state of shock characterized by a rapid fall of the blood pressure, irregularities of respiration and lack of coagulability of the blood. The reaction depended not so much on the nature of the substance as on the speed with which it was introduced. They therefore referred to it as "speed shock." They have also shown the tremendous tolerance on the part of the body to large intravenous doses of many substances and to the introduction of a great bulk of fluid, provided the rate of flow is reduced to 2 or 3 cc. per minute. Applying the drip method in clinical practice, these authors found it of great value in the prophylaxis and treatment of shock and hyperthyroidism, hemorrhage, coma, uremia and sepsis. They recommend

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