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February 20, 1937

Current Comment

JAMA. 1937;108(8):644-645. doi:10.1001/jama.1937.02780080038018

PROTAMINE AND INSULIN PREPARATIONS  From its introduction fourteen years ago, insulin underwent relatively little modification until Hagedorn1 and others of Denmark showed that the blood-sugar-lowering action of insulin was prolonged when it was combined with protamine.2 The product was first called "Protamine Insulinate," "Insulin Protaminate," or "Insulin Protamine Compound." Later the generally accepted term was Protamine Insulin. Following the announcement of Hagedorn's results, much experimental work was undertaken. Scott and Fisher,3 working at the University of Toronto, found that the addition of a zinc salt to a protamine and insulin mixture enhanced the prolongation effect of insulin in diabetic patients. Until recently the product given to investigators for clinical trials consisted of two vials. The contents were mixed by the physician before use. Various investigators in collaboration with the University of Toronto group have aided in the development of a pharmaceutically improved product of insulin, modified by