The United States recently announced an initiative for ending the HIV epidemic in the United States.1 The initiative is a joint effort of agencies across the US Department of Health and Human Services that is designed to decrease HIV transmissions in the United States by 75% over 5 years and by 90% over the next 10 years. This initiative represents the first time a coordinated effort of resources, programs, and infrastructure will focus on geographic areas and demographic groups with the highest rates of new HIV diagnoses in the United States.1 If successful, this effort would substantially decrease HIV transmission in the United States, thus ending the epidemic as an epidemiological phenomenon and could serve as a model for implementation of similar plans on a global scale.