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Clinical Trials Update
December 24/31, 2019

Statins in Childhood May Reduce CVD From Familial Hypercholesterolemia

JAMA. 2019;322(24):2375. doi:10.1001/jama.2019.20564

Patients with familial hypercholesterolemia who took a statin in childhood had a lower risk of cardiovascular disease (CVD), reported a 20-year follow-up study in the New England Journal of Medicine.

The follow-up study examined cardiovascular outcomes from 184 of 214 patients with familial hypercholesterolemia who participated in the original placebo-controlled trial evaluating 2-year pravastatin efficacy and safety. Participants began taking the statin when they were between 8 and 18 years old; the mean age at follow-up was 31.7 years. The investigators compared cardiovascular events between the now adult participants and their affected parents, for whom statins weren’t available until later in life.