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Clinical Trials Update
December 24/31, 2019

Wireless Technology Quickly Confirms TB Medication Adherence

JAMA. 2019;322(24):2375. doi:10.1001/jama.2019.20566

A sensor swallowed with tuberculosis (TB) medication accurately recorded patients’ adherence to treatment 7 days a week, reported a trial in PLOS Medicine. Patients also preferred the FDA-approved wirelessly observed therapy (WOT) over directly observed therapy (DOT).

Wirelessly observed therapy consists of an ingestion sensor and a detector patch worn on the torso. The system transmits near real-time data to the patient’s mobile device and to a secured data repository. The positive detection accuracy of WOT was 99.3%. After establishing detection accuracy, investigators then randomly assigned 61 participants with active Mycobacterium tuberculosis complex disease to WOT or DOT 5 days a week. In the WOT group, if ingestions were not remotely confirmed, the participant was contacted within 24 hours by text or cell phone to provide support.

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