A sensor swallowed with tuberculosis (TB) medication accurately recorded patients’ adherence to treatment 7 days a week, reported a trial in PLOS Medicine. Patients also preferred the FDA-approved wirelessly observed therapy (WOT) over directly observed therapy (DOT).
Wirelessly observed therapy consists of an ingestion sensor and a detector patch worn on the torso. The system transmits near real-time data to the patient’s mobile device and to a secured data repository. The positive detection accuracy of WOT was 99.3%. After establishing detection accuracy, investigators then randomly assigned 61 participants with active Mycobacterium tuberculosis complex disease to WOT or DOT 5 days a week. In the WOT group, if ingestions were not remotely confirmed, the participant was contacted within 24 hours by text or cell phone to provide support.
Slomski A. Wireless Technology Quickly Confirms TB Medication Adherence. JAMA. 2019;322(24):2375. doi:10.1001/jama.2019.20566
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