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Comment & Response
January 7, 2020

High-Dose Vitamin D Supplementation and Bone Health

Author Affiliations
  • 1Department of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
JAMA. 2020;323(1):92-93. doi:10.1001/jama.2019.18147

To the Editor In a trial exploring the effect of high-dose vitamin D supplementation on volumetric BMD and bone strength, the authors concluded that “among healthy adults, supplementation with higher doses of vitamin D did not result in improved bone health.”1 We think this statement could be misleading.

First, the study population included patients with a medical history that included conditions such as cancer, cardiovascular-related disease, type 2 diabetes, and rheumatoid arthritis. These participants cannot be considered healthy adults. Furthermore, these diseases have been previously shown to be related to vitamin D deficiency,2,3 and therefore, such patients should have been excluded.

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