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Biotech Innovations
January 14, 2020

Testing Hypothermic Preservation for Trauma Patients

JAMA. 2020;323(2):111. doi:10.1001/jama.2019.21594

Only 1 in 20 patients survive cardiac arrest from trauma-related blood loss. “Surgeons don’t have time to stop the bleeding before irreversible damage occurs to the brain and other vital organs,” trauma surgeon Samuel A. Tisherman, MD, of the University of Maryland School of Medicine in Baltimore, said in an email.

Tisherman is leading an ongoing phase 2 trial in which approximately 10 patients with penetrating trauma who suffer cardiac arrest and don’t respond to standard resuscitation will undergo emergency preservation and resuscitation (EPR). In this technique, a large amount of ice-cold saline is pumped into the aorta to quickly cool the brain and heart, followed by the rest of the body.