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September 15, 1945


JAMA. 1945;129(3):231. doi:10.1001/jama.1945.02860370053025

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To the Editor:—  In the article of Col. M. H. Barker, Major R. B. Capps and Major Frank W. Allen on infectious hepatitis (The Journal August 4, p. 997) the statement is made "The oral hippuric acid liver function test in our hands has shown practically no correlation with the clinical condition of the patient. Thus the test frequently gave relatively normal results during the acute stage and very low results in the convalescent period." This is rather surprising, since in my early studies of the test I found it consistently low in catarrhal jaundice, which many consider closely related to the entity. Recently Rennie (Am. J. M. Sc.210:18 [July] 1945) in 39 cases of infective hepatitis found the output of hippuric acid much reduced in 27 during the acute stage. In many patients the test was run serially over a period of weeks, with strikingly consistent results.

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