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September 22, 1945

PENICILLIN TREATMENT OF ACUTE PUERPERAL MASTITIS: TWENTY-FOUR CASES TREATED WITHOUT ABSCESS FORMATION

JAMA. 1945;129(4):269-270. doi:10.1001/jama.1945.02860380027007
Abstract

In acute puerperal breast infections the period of cellulitis preceding abscess formation is short, and a more satisfactory treatment than incision and drainage of the resulting abscess is desirable. Although the incidence of acute puerperal mastitis is not high, the percentage going on to abscess formation is considerable. Using standard methods of treatment, McIntosh 1 showed that approximately 18.7 per cent went on to suppuration under good hospital management. Elward and Dodek,2 McIntosh1 and more recently Harvey, Spindler and Dowdy3 reported a sharp reduction in the incidence of abscess formation when small doses of roentgen therapy were used. Sulfonamide therapy has apparently failed to achieve the clinical improvement expected, probably because of the relative ineffectiveness of such drugs on staphylpcoccic infections. Penicillin, a more energetic drug, offers a new method of treatment.

PENICILLIN AS RELATED TO ACUTE PUERPERAL MASTITIS  The bactericidal action of penicillin is selective.

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