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News From the Centers for Disease Control and Prevention
January 28, 2020

Studies Support HPV Safety

JAMA. 2020;323(4):302. doi:10.1001/jama.2019.21289

With more than 28 million doses administered since 2014, the CDC hasn’t identified any new or unexpected safety concerns with the human papillomavirus vaccine, according to a pair of CDC studies published in Pediatrics.

The first study mined data from 7244 reports of adverse events after administration of the 9-valent human papillomavirus vaccine (9vHPV) submitted to the Vaccine Adverse Event Reporting System (VAERS) between December 2014 and December 2017. About 97% of the reports weren’t serious. The most commonly reported adverse events were dizziness, syncope, headache, and injection site reactions. The authors reported 2 verified deaths after use of the vaccine but found no evidence that the vaccine caused the deaths. The overall rate of adverse event reports was 259 per million doses of 9vHPV and 7 serious adverse event reports per million doses.