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September 22, 1945


JAMA. 1945;129(4):279. doi:10.1001/jama.1945.02860380037013

Using their new fluorescein test, Lange and his associates 1 of New York Medical College have added new basic facts to the pathologic physiology of frostbite. In this test small amounts of fluorescein are injected intravenously, and the migration of the material through the blood stream and into interstitial tissue spaces is followed under ultraviolet light. Applying these new technics, the New York clinicians have suggested a promising new method for the prevention of postfrostbite gangrene. In Lange's initial experiments, 6 rabbits were depilitated on the abdomen and exposed to cold by applying the bottom of a small beaker filled with solidified carbon dioxide for periods varying from five to ninety minutes. Under this exposure the local area freezes solid and thaws after intervals varying from fifteen to twentyfive minutes, depending on the length of the exposure. For periods varying from thirty to one hundred and twenty minutes following such