Several group's of investigators have demonstrated that it is possible to attain appreciable concentrations of penicillin in the blood following the oral administration of the material in various vehicles.1 In a previous communication2 it was reported that the height and duration of the blood penicillin concentrations observed in fasting subjects after oral administration are of the same order of magnitude regardless of whether the penicillin is administered following an antacid,as a suspension in oil, as a suspension in oil mixed with beeswax or in plain water. With any of these methods approximately five times as much penicillin is required to achieve a given blood concentration when the material is administered by the oral as by the intramuscular route. From the studies of urinary excretion there was no evidence that any of the vehicles promoted the absorption of more penicillin than occurred following the ingestion of the material in
BUNN PA, McDERMOTT W, HADLEY SJ, CARTER AC. THE TREATMENT OF PNEUMOCOCCIC PNEUMONIA WITH ORALLY ADMINISTERED PENICILLIN. JAMA. 1945;129(5):320–327. doi:10.1001/jama.1945.02860390006002
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