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February 4, 2020

DNA Prime Editing: A New CRISPR-Based Method to Correct Most Disease-Causing Mutations

JAMA. 2020;323(5):405-406. doi:10.1001/jama.2019.21827

A new genome editing method may overcome critical barriers to correcting disease-causing genetic mutations. The approach draws on the popular clustered regularly interspaced short palindromic repeat (CRISPR)–associated 9 (Cas9) technology but avoids some of its undesired effects on DNA. In principle, the technique—called prime editing—could correct an estimated 89% of genetic variants known to be associated with human diseases.