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September 29, 1945

Ultracentrifugal Studies on Serum and Serum Fractions

JAMA. 1945;129(5):415. doi:10.1001/jama.1945.02860390101028

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The appearance of this volume summarizing work carried out from 1939 to 1944 at the Institute of Physical Chemistry at Uppsala is timely, since it makes available both the experimental work and the approach to problems of an important group of scientists with whom contact has been almost nonexistent during the war. The work throughout emphasizes the necessity for the use both of ultracentrifugal and of electrophoretic analysis as a guide to the study of mixtures of proteins, a point of view which is also generally accepted in this country. Dr. Pedersen reports several fundamental contributions, among which are the establishment of the profound influence of the density of the solution centrifuged on the protein pattern with the resultant demonstration and separation of the X-protein of human serum, a high molecular weight dissociable complex of albumin and globulin containing large amounts of lipid and perhaps carbohydrate. Also of great interest

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