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JAMA Insights
Clinical Update
February 7, 2020

Diagnosis and Management of Primary Hyperparathyroidism

Author Affiliations
  • 1Department of Surgery, Section of Endocrine Surgery, UCLA David Geffen School of Medicine, Los Angeles, California
  • 2Department of Surgery, Section of Endocrine Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois
JAMA. Published online February 7, 2020. doi:10.1001/jama.2020.0538

Primary hyperparathyroidism (PHPT) is a common disorder of dysregulated calcium homeostasis. In 2013, its incidence in the US is estimated at 66 per 100 000 person-years among women and 25 per 100 000 among men.1 The adoption of routine chemistry panel testing in the 1970s led to increased discovery of PHPT and changed its clinical presentation in developed nations from a rare, highly symptomatic disease to a milder, more subtle condition.

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