To the Editor As ever more critical care trials fail to demonstrate a mortality effect,1,2 we believe that randomized trials can be made more efficient and informative by the careful choice of a disease-oriented end point rather than mortality.
de Grooth H, Elbers PWG, Vincent J. Vitamin C for Sepsis and Acute Respiratory Failure. JAMA. 2020;323(8):792. doi:10.1001/jama.2019.21981
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