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Comment & Response
February 25, 2020

Vitamin C for Sepsis and Acute Respiratory Failure

Author Affiliations
  • 1Department of Intensive Care, Amsterdam UMC, Location VUmc, Amsterdam, the Netherlands
  • 2Department of Intensive Care, Erasmus Hospital, Brussels, Belgium
JAMA. 2020;323(8):792. doi:10.1001/jama.2019.21981

To the Editor As ever more critical care trials fail to demonstrate a mortality effect,1,2 we believe that randomized trials can be made more efficient and informative by the careful choice of a disease-oriented end point rather than mortality.

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