Acute suppurative otitis media is a problem of great importance to the pediatrician, internist and otologist who encounter it frequently either as an isolated disease or in the course of such infections as scarlet fever or measles. If improperly or inadequately treated, its complications may lead to partial or total loss of auditory function or, in some instances, may seriously endanger life. The development of a method of treatment which will eliminate serious complications and reduce the incidence of mastoidectomy and other operative procedures is most desirable and is a matter which has attracted the attention of many investigators for a long time.
Before the era of specific chemotherapeutic agents, therapy of acute suppurative otitis media was directed mainly to the local application of various agents through the external auditory canal for the purpose of reducing pain and killing the bacteria that were present in the middle ear. Such methods
WEINSTEIN L, ATHERTON HB. THE TREATMENT OF ACUTE SUPPURATIVE OTITIS MEDIA WITH PENICILLIN. JAMA. 1945;129(7):503–508. doi:10.1001/jama.1945.02860410019005
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