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October 13, 1945

THE ABUSE OF ENDOCRINE THERAPY IN GYNECOLOGY

JAMA. 1945;129(7):508-509. doi:10.1001/jama.1945.02860410024006
Abstract

An analysis of a group of cases seen in the Department of Obstetrics and Gynecology of the University of Michigan Hospital has disclosed a need for greater clarification in the management of the gynecologic patient. The abuse of endocrine therapy prior to adequate diagnosis is illustrated in the cases reported here and summarized in the table.

REPORT OF CASES 

Case 1.—  A married nulliparous woman aged 23 gave a history of normal menstrual periods until five months prior to admittance. She reported intermittent, bright red vaginal bleeding for one month previous to the institution of diethylstilbestrol therapy. She had passed no tissue but soiled one to two pads daily throughout a four month period of endocrine treatment. Pelvic examination had not been made and the patient was referred to us with the diagnosis "functional bleeding."Admittance pelvic examination revealed nothing unusual. The Aschheim-Zondek test was negative. Dilation and curettage revealed

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