The increased incidence of infectious jaundice during the war has focused attention on the need for simple tests which will aid in the early detection of the disease and in following its course. The observation of Neefe and Stokes1 that bilirubiti may appear in the urine in cases of experimentally induced hepatitis before any elevation of the total serum bilirubin is observed is in itself indicative of the need of a simple sensitive and reliable procedure by means of which large numbers of urine samples can be examined rapidly for the presence of bilirubin. It is, of course, well known that the urine often becomes dark in cases of infectious hepatitis one or more days before the appearance of jaundice, and in some instances of hepatitis without jaundice the presence of dark urine for a short period of time early in the course of the disease may be the
Hawkinson V, Watson CJ, Turner RH. A MODIFICATION OF HARRISON'S TEST FOR BILIRUBIN IN THE URINE ESPECIALLY SUITED FOR MASS AND SERIAL USAGE. JAMA. 1945;129(7):514–515. doi:10.1001/jama.1945.92860410001009
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