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October 13, 1945

Microbial Antagonisms and Antibiotic Substances

JAMA. 1945;129(7):531. doi:10.1001/jama.1945.02860410047019

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The application of antibiotics to the management of human disease has stimulated a tremendous interest in the subject of microbial antagonisms. It is indeed fortunate that Professor Waksman has responded to the renewed interest in this field with an authoritative and comprehensive survey of the subject. Knowledge of the antagonistic interrelationships of microbes is not recent. These phenomena have attracted the attention of soil biologists for many years. The author's original observations are well known to students in this field. His purpose in this monograph is to present a review of the antagonistic activities of micro-organisms, with emphasis on these associations as they occur in nature and their relation to human, animal and plant diseases, and to discuss the chemistry and mode of action of the known antibiotics and their application.to the control of disease.

The subject matter is presented in fourteen chapters. The introductory chapters are concerned with microbial

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