In order to evaluate the local use of penicillin in infections of the ear, nose and throat, a study of a group of patients was begun in February 1945 for the purpose of taking advantage of the seasonal peak in the incidence of upper respiratory infections. The study continued for three months. During this period approximately 500 patients were treated. Of this group the case records were complete enough in 339 to be used for statistical purposes. Cultures were obtained in 403 patients, and these results are also tabulated.
Although the exciting cause of acute rhinitis (the common cold) is generally accepted to be a virus, its effects are relatively transient. It is the activation of a host of pathogenic pyogenic organisms by the virus which produces the many local and remote pathologic processes which constitutes the main problem in the management of upper respiratory infections. Fortunately, the majority of
WOODWARD FD, HOLT T. LOCAL USE OF PENICILLIN IN INFECTIONS OF THE EAR, NOSE AND THROAT: RESULTS OF TREATMENT. JAMA. 1945;129(9):589–592. doi:10.1001/jama.1945.02860430005002
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