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October 27, 1945

ARTHRITIS RESEMBLING REITER'S SYNDROME: OBSERVATIONS ON TWENTY-FIVE CASES

JAMA. 1945;129(9):593-595. doi:10.1001/jama.1945.02860430009003
Abstract

At Ashburn General Hospital, a center designated by the Army for the treatment of arthritis, we have had the opportunity of seeing many unusual manifestations of rheumatic disease. We have been impressed by the apparent frequency of a syndrome characterized by arthritis, nonspecific urethritis and often conjunctivitis. Because of the sparsity of previous clinical reports, we believe it advisable to report our preliminary observations.

In 1916 Reiter1 described a clinical syndrome with these characteristics. Since that time only 50 cases in twenty-six communications have been reported, and only a few of these reports have appeared in American journals.2 It is noteworthy that 22 of the reported cases have occurred in soldiers on active duty in World Wars I and II.

Various organisms, including a spirochete, a staphylococcus, an enterococcus and a filtrable virus, have been suggested as causal agents, but none have been confirmed, and the symptom complex

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