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October 27, 1945

Current Comment

JAMA. 1945;129(9):620. doi:10.1001/jama.1945.02860430036013

STREPTOMYCIN AND PROMIN IN EXPERIMENTAL TUBERCULOSIS  Guinea pigs infected with tuberculosis were employed by Smith and McClosky1 to determine whether streptomycin has any beneficial effect, to compare the results of streptomycin therapy with the sulfone promin and to explore the possibilities of combined treatment with these two cheniotherapeutic agents. Under the experimental conditions of treatment streptomycin injected intramuscularly produced a definitely greater chemotherapeutic effect than promin. The dose of promin used was about one-half the maximum tolerated dose, while the dose of streptomycin used was less than one twentieth of its maximum tolerated dose; hence streptomycin had a therapeutic index at least ten times that of promin. Neither of these agents used alone completely eradicated the tuberculous process. Larger doses and better methods of administration may well increase the therapeutic effect of streptomycin. By the application of a suitable combination of promin and streptomycin, Smith and McClosky obtained results