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November 3, 1945

The Bacterial Cell in Its Relation to Problems of Virulence, Immunity and Chemotherapy

JAMA. 1945;129(10):713. doi:10.1001/jama.1945.02860440061025

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Knowledge of cellular immunology has lagged in development behind cellular pathology. Summarizing and integrating presentations in book form of what is known of cellular immunology have been scarce and inadequate. This monograph is a timely and much needed contribution. Dubos has succeeded admirably in blending in organic fashion results of widely scattered biochemical, physical and immunologic studies. An introductory chapter deals with problems, materials and methods. The subjects of cytology of bacteria and their physicochemical and staining properties, cellular structure, variability, virulence, immunization against bacterial infection, and bacteriostatic and bactericidal agents are treated in separate chapters. The concluding chapter, on trends and perspectives, is stimulating in its philosophical vein. Wisely selected quotations at thebeginning of each chapter introduce a broad contemplative element and add much to the readability. There is an appendix by Robinow on the nuclear apparatus and cell structure of rodshaped bacteria. The presentation is lucid, complete and

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