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November 10, 1945

CONGENITAL ANOMALIES FOLLOWING MATERNAL RUBELLA IN EARLY WEEKS OF PREGNANCY: WITH SPECIAL EMPHASIS ON CONGENITAL CATARACT

JAMA. 1945;129(11):719-723. doi:10.1001/jama.1945.02860450005002
Abstract

In 1942 Dr. N. McAlister Gregg1 of Australia published the first report of congenital anomalies in infants born of mothers who had contracted exanthematous disease in the early weeks of pregnancy. Since then other reports have appeared in increasing number, both in Australia and in this country. In this communication the literature is reviewed and 9 additional cases are reported.

REVIEW OF LITERATURE  Although Gregg's report was carefully reviewed by Reese,2 a brief summary of the important facts is included here. In Australia in 1940 there occurred a severe epidemic of rubella, which for the most part affected young persons who had not been exposed in previous epidemics. It is noteworthy that most of those women who were affected during pregnancy were primiparas. The description of the disease was pleomorphic and the diagnosis was often in question because there was a concurrent epidemic of sore throat which had

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