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Comment & Response
April 28, 2020

Health Outcomes With Vitamin D Supplementation—Reply

Author Affiliations
  • 1Department of Medicine, Duke University School of Medicine, Durham, North Carolina
JAMA. 2020;323(16):1619. doi:10.1001/jama.2020.2645

In Reply Our Editorial accompanied the report of the VITAL-DKD trial.1,2 The focus of that article and our Editorial was the lack of benefit of vitamin D supplementation over placebo for prevention of chronic kidney disease end points. We concluded that the VITAL-DKD and D2d trials “provide strong clinical trial–grade evidence against … kidney-protective effects of routine vitamin D3 supplementation in the vast majority of patients with prediabetes or established type 2 diabetes,” and emphasized the discrepancy between the “negative” results of these trials relative to previous observational studies that suggested benefits of higher vitamin D levels.

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