Like syphilis, sickle cell anemia may present many clinical syndromes.1 Some of these are easily recognizable, while others may imitate many disease states such as rheumatic fever, tuberculosis, Hodgkin's disease and acute surgical diseases of the abdomen, only to mention a few, to an extent that the differential diagnosis is learned only after proper hematologic study. Like syphilis, the disease may beso subtle as not to enter the mind of the clinician. Because of the fact that sickle cell anemia is such a great imitator and because it may remain so subtle, it is necessary, again as in syphilis, to study the blood routinely for sickle cell anemia in all Negro patients. In the past routine studies have not been done, as preparations of blood for sickling have offered certain difficulties.2 A simple, rapid and accurate (the diagnostic parameter) method, described elsewhere,3 offers itself for the routine
WINSOR T, BURCH GE. SICKLE. CELL ANEMIA, "A GREAT MASQUERADER": EASILY RECOGNIZABLE WITH ROUTINE USE OF DIAGNOSTIC PARAMETER. JAMA. 1945;129(12):793–796. doi:10.1001/jama.1945.02860460017004
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