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November 17, 1945

THE MANAGEMENT OF CHRONIC MALARIA BETWEEN ATTACKS: WITH SPECIAL REFERENCE TO THE EFFECT OF NICOTINIC ACID ON MALARIAL HEADACHE

JAMA. 1945;129(12):796-798. doi:10.1001/jama.1945.02860460020005
Abstract

Since its earliest description in ancient times, malaria has been the subject of repeated writings by a host of authors and scientific investigators. For the past sixty years, following the discovery of Laveran in 1884 of the malarial plasmodium in the blood of malarial patients, a tremendous impetus has been added to the interest arid scientific investigation of this disease. Eleven years (1895) after Laveran's epochal demonstration Sir Ronald Ross discovered the mosquito vector in the transmission of malaria to human beings and thus established the second important milestone in our advance against this age-old scourge. These two outstanding contributions served to stimulate further study of this disease, and at the present time malaria is being widely investigated by many epidemiologists, military physicians and public health workers.

Because of the episodic nature of chronic malaria and the long asymptomatic intervals which characterize the course of the disease all previous studies,

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