The prognosis in any case of gonorrheal arthritis is dependent on (1) the virulence of the offending gonococcus strain, (2) the persistence of the local infection, (3) the resistance of the individual and (4) the promptness with which appropriate treatment is instituted. However, the prompt institution of appropriate treatment is dependent on one's ability to distinguish gonorrheal arthritis from the other arthritides. Such differentiation is at times difficult because one can neither elicit a history of previous gonorrheal infection nor isolate the gonococcus from the focus of infection. In such instances the need of a laboratory test indicating the possible existence of a gonococcic infection is all too apparent.
Is the complement fixation test for the gonococcus as it is now done as a routine in public health laboratories sufficiently accurate to warrant its employment as a diagnostic aid in the study of arthritic patients? In order to answer this
WARREN CF, HINTON WA, BAUER W. SIGNIFICANCE OF GONOCOCCUS COMPLEMENT FIXATION TEST AS A DIAGNOSTIC AID: IN THE STUDY OF ARTHRITIS. JAMA. 1937;108(15):1241–1247. doi:10.1001/jama.1937.02780150015004
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