For only the second time, a patient with HIV who received an allogeneic hematopoietic stem cell transplant from a donor with an HIV resistance gene appears to have been cured of the disease, according to a recent study.
Known in medical studies as “the London patient,” 40-year-old Adam Castillejo underwent the transplant for Hodgkin lymphoma. In 2011, the first such case was reported in Berlin. That patient, Timothy Ray Brown, underwent total body irradiation and 2 stem cell transplants from a donor with an abnormal CCR5 gene, which confers resistance to HIV. Brown also underwent chemotherapy to kill any residual virus. Castillejo underwent similar treatment, with 1 stem cell transplant from a donor having the CCR5 defect and chemotherapy but not total body irradiation.
Kuehn BM. Study Suggests a Second Patient Has Been Cured of HIV. JAMA. 2020;323(19):1886. doi:10.1001/jama.2020.7626
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: