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Global Health
May 19, 2020

Study Suggests a Second Patient Has Been Cured of HIV

JAMA. 2020;323(19):1886. doi:10.1001/jama.2020.7626

For only the second time, a patient with HIV who received an allogeneic hematopoietic stem cell transplant from a donor with an HIV resistance gene appears to have been cured of the disease, according to a recent study.

Known in medical studies as “the London patient,” 40-year-old Adam Castillejo underwent the transplant for Hodgkin lymphoma. In 2011, the first such case was reported in Berlin. That patient, Timothy Ray Brown, underwent total body irradiation and 2 stem cell transplants from a donor with an abnormal CCR5 gene, which confers resistance to HIV. Brown also underwent chemotherapy to kill any residual virus. Castillejo underwent similar treatment, with 1 stem cell transplant from a donor having the CCR5 defect and chemotherapy but not total body irradiation.