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November 24, 1945

PENICILLIN IN THE TREATMENT OF SUBACUTE BACTERIAL ENDOCARDITIS: A PRELIMINARY REPORT ON TWENTY CASES TREATED OVER ONE YEAR AGO

JAMA. 1945;129(13):841-843. doi:10.1001/jama.1945.02860470001001
Abstract

In June 1942 an intern at the Philadelphia General Hospital suffering with subacute bacterial endocarditis was treated unsuccessfully by us with penicillin. The total dosage was 225,000 units given over a period of seven days. Similar results with relatively small dosage were observed by others. Subsequent to these early reports, Loewe and his associates1 and Dawson and Hobby2 were successful in the treatment of this disease by employing larger amounts of penicillin over longer periods of time. Following these encouraging results the Committee on Medical Research began a more extensive study of the use of penicillin in this disease. and this report represents a part of that investigation.

MATERIAL  This paper deals with the use of penicillin in the treatment of 20 cases3 of subacute bacterial endocarditis in which therapy was started over one year ago. Not included in this report are 2 moribund patients, 1 of

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