Gas gangrene has been reported in fairly large numbers in this war. Forty-four cases with 13 deaths and 8 additional amputations in recovered patients were reported by MacLennon1 in British army casualties in the North African campaign, an incidence of between 6 and 7 per thousand wounded. Twenty cases were seen by Power2 in 6,000 casualties in the fighting in Normandy. In 16 of these patients there were 10 amputations and 2 deaths.
Despite increase in the potency of antiserums and chemotherapy, local and systemic, results of treatment of gas gangrene are not much better than they were twenty-five years ago.1 A consideration of the problem makes it obvious that the reason for failure is twofold : There is an inadequacy in blood supply to necrotic tissue and therefore the amount of penicillin reaching this tissue at the usual blood level is completely inadequate. This may
Naide M, Saÿen A. TREATMENT OF SEVERE NECROTIC LESIONS: HIGHER PENICILLIN DOSAGE WITH SIMULTANEOUS REGIONAL SYMPATHETIC BLOCK. JAMA. 1945;129(13):869–870. doi:10.1001/jama.1945.92860470002007a
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