Several authors1 have published reports on the cerebral electroactivity of patients with syphilis of the central nervous system. They agree that no correlation exists between the degree of abnormality of the electroencephalographic pattern and the type, the severity or the duration of the disorder. In the majority of the cases a definitely but nonspecifically abnormal electroencephalogram, or an electroencephalogram on the borderline between normal and abnormal, is found. However, enough patients with various types of neurosyphilitic disorders present electroencephalographic records "within normal limits" to detach from this procedure any immediate diagnostic significance.
After fever treatment has been completed, the abnormal cerebral electroactivity of neurosyphilitic patients often returns to normal or at least improves greatly. The changes of a previously abnormal pattern to normal seem to be correlated with the therapeutic success. Patients whose pathologic process is arrested by the fever but who retain residual symptomatology also retain many of
CALLAWAY JL, LÖWENBACH H, NOOJIN RO, KUHN BH, RILEY KA. ELECTROENCEPHALOGRAPHIC FINDINGS IN CENTRAL NERVOUS SYSTEM SYPHILIS: BEFORE AND AFTER TREATMENT WITH PENICILLIN. JAMA. 1945;129(14):938–939. doi:10.1001/jama.1945.02860480018005
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