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December 1, 1945

Current Comment

JAMA. 1945;129(14):954. doi:10.1001/jama.1945.02860480034011

TREATMENT OF PEPTIC ULCER WITH AMINO ACIDS  A recent report by Co Tui and his co-workers1 from several departments of the New York University College of Medicine presents some rather astonishing results from the treatment of patients with peptic ulcer by high amino acid feedings. Twelve patients with duodenal ulcer, 5 with combined duodenal and gastric ulcer, 7 with gastric ulcer, 1 with suspected marginal ulcer and 1 with radiologically confirmed marginal ulcer were placed on feedings at two hour intervals of dextrimaltose and a preparation made by hydrolyzing amino acids. Included in the group were the 4 original patients with peptic ulcer who were given the treatment prior to contemplated gastrectomy. The mixture fed contained from 0.5 to 0.8 Gm. of nitrogen and 40 to 50 calories per kilogram of body weight in twentyfour hours. The length of the ulcer history varied from one month to