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December 1, 1945

Foreign Letters

JAMA. 1945;129(14):974-975. doi:10.1001/jama.1945.02860480054016

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LONDON  (From Our Regular Correspondent)Oct. 27, 1945.

Penicillin in Ophthalmology  Professor Arnold Sorsby spoke at the Section of Ophthalmology of the Royal Society of Medicine on penicillin in ophthalmology. Although penicillin is commonly regarded as nontoxic and readily diffusible, these qualities do not apply to its ophthalmologic use. It is possible to give penicillin in daily subconjunctival injections if the total dosage is not more than 500 or 600 units. Professor Sorsby has observed only 1 case of allergic reaction—in an infant with ophthalmia neonatorum; the instillation of a drop of penicillin into each eye caused severe edema of the lids. Penicillin used locally was effective for the organisms in ophthalmia neonatorum. In 98 cases using 2,500 units of penicillin per cubic centimeter there were 78 cures, 13 relapses and 7 failures. The frequency of instillation as well as the concentration used was important. When penicillin was applied at

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