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July 7, 2020

Insulin Given With DPP4 Inhibitors Might Protect Blood Vessels in Patients With Diabetes

JAMA. 2020;324(1):15-16. doi:10.1001/jama.2020.10110

Investigators have uncovered new insights into how abnormal insulin signaling may contribute to the heart disease and atherosclerosis that often accompany type 2 diabetes, and why aggressive insulin treatment does not help prevent these cardiovascular outcomes. They’ve also found a way to correct insulin signaling to protect blood vessels.

“In mouse models and other basic science settings, insulin treatment has beneficial antioxidant effects on the vascular wall and improves overall health beyond lowering blood glucose levels, but surprisingly, cardiovascular benefits have not been seen in large randomized clinical trials of diabetic patients,” Charalambos Antoniades, MD, PhD, a professor of cardiovascular medicine at the University of Oxford, said by email. “This was a mystery for many years.”

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